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Research in flies and mice supports USC researcher’s theory that the sexes age differently.

A study on human cells reveals how cellular aging affects the 3-D architecture of chromosomes.

Multipotential mesenchymal stromal cells (MSC) are present as a rare subpopulation within any type of stroma in the body of higher animals. Prominently, MSC have been recognized to reside in perivascular locations, supposedly maintaining blood vessel integrity. During tissue damage and injury, MSC/pericytes become activated, evade from their perivascular niche and are thus assumed to support wound healing and tissue regeneration. In vitro MSC exhibit demonstrated capabilities to differentiate in...

Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging.

PRMT7 is required for muscle stem cell self-renewal and regenerative capacity in vivo. PRMT7 deletion causes senescence of activated muscle stem cells. This entry into senescence is associated with persistent expression of p21.

An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.

Ironically, antiaging product advertisements often promise to “slow down the clock.” But abolishing the circadian clock—for example, by knocking out Bmal1, a core clock gene—accelerates aging and shortens the life span in mice. As a result, Bmal1 knockout mice often serve as a model system in studies of the role of circadian rhythms in the aging process. Now Yang et al. show that the developmental timing of Bmal1 expression influences the circadian clock’s effects on aging and survival.

Researchers have revealed a list of proteins most associated with aging and age-related disease including Alzheimer's. The team has found that short and highly charged proteins are most vulnerable to oxidation, which damages proteins in aging cells.

Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy metabolism. We hypothesized that in CR ghrelin has a role in protecting aging-related diseases.

Scientists have cracked the secret of why some people live a healthy and physically independent life over the age of 100.