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The Hallmarks of Aging

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The Hallmarks of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and bioch...
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| Categories: | Tags: Aging signs, aging biomarkers, genome, telomeres, epigenetic alterations, proteostasis, nutrients, mitochondrial dysfunction, cell aging, stem cells, intercellular interaction, genetics | Comments: (0) | View Count: (1025)
03

The Hallmarks of Aging

posted on
The Hallmarks of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and bioch...
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| Categories: | Tags: aging hallmarks, human pathologies, including cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication | Comments: (0) | View Count: (1043)
Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study
Purpose: Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase activator (TA)-65 in early macular degeneration. This study, focusing on early macular degeneration, p...
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| Categories: | Tags: drusen, macular degeneration, micro-perimetry, senescence, telomerase activation, telomere | Comments: (0) | View Count: (1655)
Inflammation, not telomere length, predicts healthy longevity of centenarians
Scientists have cracked the secret of why some people live a healthy and physically independent life over the age of 100.
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| Categories: Uncategorized | Tags: Inflammation, telomere, longevity, centenarians, aging, antiage | Comments: (0) | View Count: (1473)