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Patient-specific age: the other side of the coin in advanced mesenchymal stem cell therapy
Multipotential mesenchymal stromal cells (MSC) are present as a rare subpopulation within any type of stroma in the body of higher animals. Prominently, MSC have been recognized to reside in perivascular locations, supposedly maintaining blood vessel integrity. During tissue damage and injury, MSC/pericytes become activated, evade from their perivascular niche and are thus assumed to support wound healing and tissue regeneration. In vitro MSC exhibit demonstrated capabilities to differentiate in...
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| Categories: | Tags: vascular niche, cell-based therapy, aging biology, cellular dysfunction, age-associated pathology, regenerative medicine | Comments: (0) | View Count: (1404)