News

Purpose: Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase activator (TA)-65 in early macular degeneration. This study, focusing on early macular degeneration, p...

Text-mining analysis finds that studies fall short of best practice — despite guidelines introduced in 2010. The largest-ever analysis of the quality of mouse studies reveals that as recently as 2014, only around 50% of research papers recorded both the sex and age of the animals used — key details needed for others to assess and reproduce the research1.

Summary Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI compartments contain specific microbiota, and microbiota dysbiosis is associated with intestinal dysfunction. Dysbiosis develops in aging intestines, yet how this relates to changes in GI compartmentalization remains unclear. The Drosophila GI tract is an accessible model to address this question. Here we show that the stomach-like copper cell region (CCR) in the middle midgut controls distri...

Vanderbilt University Medical Center nephrologist and Associate Professor of Medicine Dr. William H. Fissell IV, is making major progress on a first-of-its kind device to free kidney patients from dialysis. He is building an implantable artificial kidney with microchip filters and living kidney cells that will be powered by a patient’s own heart.

Smart nanocrystals could help deliver chemotherapy drugs more efficiently and might be able to pass through the blood-brain barrier.

A round-up of recent discoveries in genomics.

In the fierce debate about CRISPR gene editing, it’s time to give patients a voice.

Boil them, deep-freeze them, crush them, dry them out or blast them into space: tardigrades will survive it all and come back for more.

The difference between biological age and chronological age can be used to predict cancer.

Muscle stem cells (MuSCs) exhibit distinct behavior during successive phases of developmental myogenesis. However, how their transition to adulthood is regulated is poorly understood. Here, we show that fetal MuSCs resist progenitor specification and exhibit altered division dynamics, intrinsic features that are progressively lost postnatally.