News

As I start to look at the emerging trends of 2017 from the vantage of IndieBio, where we see hundreds of biotech startup applications and technologies per year, a few key themes are already emerging. Even as political landscapes change, science and technology continue to push forward.

Looking for a fountain of youth? You may need to search no further than your sneakers. Exercise, particularly high-intensity interval training, encourages your cells to make more proteins to feed their energy-producing machinery -- and this arrests the aging process, according to a new study published Tuesday in the journal Cell Metabolism.

As we age, some systems in the body don’t work as well. Eyesight weakens, there can be some minor age related memory loss and many people move a little slower and don’t stay as active. Sleep disturbances are common as well, but recent research shows that sleeping patterns could be an indicator of another problem seen in the elderly: dementia. Currently estimates put the number of people dealing with some form of dementia at about 46 million globally. In the United States, there are approxima...

In a recent study, Rochester scientists made two important contributions to DNA damage research. First, though scientists could previously point to an association between DNA damage and aging, the Rochester group has demonstrated a causal relationship between reduced DNA damage and extended lifespan. Second, the researchers have identified a cellular factor—an enzyme called topoisomerase 2, or Top2, implicated in DNA damage—that can be targeted to reduce that damage. The findings are published...

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and bioch...

We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control.

We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control.

Direct induction of induced hepatocytes (iHeps) from fibroblasts holds potential as a strategy for regenerative medicine but until now has only been shown in culture settings. Here, we describe in vivo iHep formation using transcription factor induction and genetic fate tracing in mouse models of chronic liver disease.

This could explain why obese people have lower mortality rates. For the first time, scientists have discovered a connection between a cell's fat content and its lifespan, which could explain the 'obesity paradox' that's been puzzling scientists for decades: why obese people have the lowest all-cause mortality rates, whereas the rate for those who are fit and lean is higher.

Interventions into the degenerative aging process are still only in their infancy. A long war will need to be fought from basic research on cell cultures and animal models to deliver, eventually, effective, safe and widely available human anti-aging therapies.