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Purpose of the Study: Older homeless adults living in shelters have high rates of geriatric conditions, which may increase their risk for acute care use and nursing home placement. However, a minority of homeless adults stay in shelters and the prevalence of geriatric conditions among homeless adults living in other environments is unknown. We determined the prevalence of common geriatric conditions in a cohort of older homeless adults, and whether the prevalence of these conditions differs acro...

Direct induction of induced hepatocytes (iHeps) from fibroblasts holds potential as a strategy for regenerative medicine but until now has only been shown in culture settings. Here, we describe in vivo iHep formation using transcription factor induction and genetic fate tracing in mouse models of chronic liver disease.

This could explain why obese people have lower mortality rates. For the first time, scientists have discovered a connection between a cell's fat content and its lifespan, which could explain the 'obesity paradox' that's been puzzling scientists for decades: why obese people have the lowest all-cause mortality rates, whereas the rate for those who are fit and lean is higher.

A confounding aspect of biological ageing is the nature and role of senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of the same phenomenon instigated by different sources, or if each of these is distinct, and how they are associated with ageing.

To image β-amyloid (Aβ) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and Aβ are correlated, and compare the spatial distribution of Aβ to Alzheimer disease (AD).

Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a potential alternative source for red blood cell transfusion. However, when using traditional methods with embryoid bodies, ES cell-derived erythroid cells predominantly express embryonic type ɛ-globin, with lesser fetal type γ-globin and very little adult type β-globin.

Interventions into the degenerative aging process are still only in their infancy. A long war will need to be fought from basic research on cell cultures and animal models to deliver, eventually, effective, safe and widely available human anti-aging therapies.

Scientists have discovered more than 200 genes linked to ageing and have found switching them off extends life Switching off parts of the genetic code could help people live longer, scientists believe