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Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging.

When the anterior pituitary gland is damaged—through tumours, infections, or even genetic factors—many different disorders can arise, some of which—like insufficient ACTH—are life threatening.

PRMT7 is required for muscle stem cell self-renewal and regenerative capacity in vivo. PRMT7 deletion causes senescence of activated muscle stem cells. This entry into senescence is associated with persistent expression of p21.